​Associate Director, Protein Characterization

Location: Boston, MA

Company Overview

A unique, well-funded, privately held Start-Up with a novel Antibody Therapy platform is seeking a highly motivated individual to lead their Protein Characterization efforts. The company was established in 2019 and has made significant progress in programs with wide therapeutic application in Inflammation, Cardiac diseases and Cancer. It boasts of an intellectually stimulating, positive and collaborative environment with stellar academic and industry leaders as cofounders.

​

Job Summary

The Principal Scientist/Associate Director, Protein Characterization will be a highly motivated self-starter with relevant experience in Analytical Development of Protein Biologics. The candidate will have a strong understanding of protein-based assays and work on multiple antibody campaigns in close collaboration with the Protein Sciences team. This will be a visible role reporting to the VP of Research.

​

Responsibilities

• Analyze and qualify different protein modalities using biochemical assays like Analytical chromatography (SEC), HPLC, SDS-PAGE, AC-SINS, CE-SDS, endotoxin assay, among others

• Perform manufacturing and developability assessments and stability studies for proteins under different conditions

• Characterize proteins and study binding using DSF, DSC, BLI (Octet), SPR, ELISA based Immunoassays, Western Blotting and other biophysical and biochemical assays

• Perform bacterial and mammalian protein purification to make mg quantities of proteins for downstream applications (like PK studies)

• Contribute to support lead candidate selection

• Support implementation of automation approaches as required to maximize productivity

• Collaborate with external partners to establish novel analytical methods for the company

• Facilitate method transfer to CDMOs for GMP manufacturing campaigns

• Analyze and present data, and troubleshoot issues as they arise

• Foster, nurture and leverage constructive relationships across other internal functional groups

​

Requirements

• PhD in Biochemistry, Biophysics, Molecular Biology, Analytical Chemistry or a related discipline

• 5+ years of industry experience leading protein analytical sciences efforts

• Solid understanding and experience of protein-based assays like analytical chromatography on HPLC/UPLC, AC-SINS, stability testing, isoelectric focusing, SPR, ITC, DSF, Mass Spectrometry and protein interaction and PTM detection

• Hands-on experience with characterizing protein biologics like antibodies, enzymes and fusion proteins in an industry setting with a strong preference for antibodies

• Experience with developability assessment campaigns is highly desirable

• Experience with automation systems will be valuable

• Exceptional communication skills, both written and oral, and an ability to communicate complex issues to a range of audience

• Ability to learn new skills and adapt to challenges in a fast-paced environment

​

Salary: On application