Director (Statistical Science)

Location United Kingdom
Discipline: Biometrics
Job type: Permanent
Salary: £180000 to £270000
Contact name: Daniel Cheetham

Contact email:
Contact phone: +1 617 982 1238
Job ref: 22667
Published: about 1 month ago
Expiry date: 19 January 2022

Ashley Clarke @ RBW consulting is currently recruiting for a Director of Statistical Science for a global Pharmaceutical company on a permanent contract. The candidate will be expected to be office and home based.  

The successful candidate will join a leading global pharmaceutical company. They employ the best minds to help push the boundaries of human and data science. Their global research and developments centres are renowned for their innovations and collaborative environment to really push the boundaries of medical science.

You will be given access to cutting-edge in-house technology, allowing you to work on a global scale. My client want professionals with the same passion and drive to discover and develop medicines to combat   

Job Overview

Will play an important part in our growing Global Medical Affairs/Payer Biometrics statistics group which sits within Oncology Biometrics. This role combines individual statistical design and strategic contributions with the opportunity to lead, manage, and develop a small group of Statisticians.

Reports to the Head of GMA/Payer Biostatistics and will be responsible for the delivery of services to the groups two key stakeholders, GMA and Oncology Market Access and Pricing (OMAP). For GMA, the group provides statistical support for interventional and Real World Evidence (RWE) studies, including developing design options and providing high quality decision support. For OMAP, the group provides statistical support for the Global Oncology Payer Function via the application of quantitative skills to support decision-making processes and value demonstration, including contributing to Health Technology Assessment (HTA) submissions.


you will line manage and develop a team of statisticians. You will be expected to:

  • Take on a leadership role and drive statistical thinking in cross-functional team projects
  • Lead, manage, and develop a global group of statisticians, ensuring the successful delivery of projects while also considering the development needs of the team
  • Contribute to strategic planning and quantitative decision making
  • Participate in adapting and developing statistical methodology
  • Contribute to development of new procedures and standards to increase quality, efficiency, and effectiveness
  • Influence key stakeholders and governance
  • Act as a technical expert in interactions with external providers and collaborators
  • Work with regulatory and payer agencies, e.g. attending meetings, answering questions


Provide mentoring to more junior staff and present at internal training seminars


  • MSc or Ph.D. Statistics, Biostatistics, or Mathematics (containing a substantial mathematical component).
  • Experience of leading projects and people in a pharmaceutical or CRO environment.
  • Publication experience and/or experience of presenting at external meetings (e.g. ISPOR, PSI)
  • Programming expertise in R, WinBugs and/or SAS.
  • Experience of reimbursement submissions in key markets (e.g. UK and Germany.).
  • Regulatory submission experience in key markets (e.g. EU and USA.)
  • Application of indirect comparison methodology (e.g. Bayesian/Frequentist NMA and MAIC/STC methodologies).
  • Experience of performing adjustment for treatment switching/cross-over within clinical trials (e.g. RPSFT and IPCW methodology.).
  • Analysis of health utility data including mapping and value set application.
  • Application of causal inference models to clinical trial and RWE data.
  • Experience of working with RWE datasets and registries (e.g. Flatiron.).

To find out more about this fantastic opportunity or to discuss other open positions which may be of interest please contact Ashley Clarke on +44 (0) 1273 952 363 and send your CV through using the apply button on this page.