Principal Scientist, Protein Sciences - Antibody Therapy Biotech

Location Boston
Discipline: Pre-Clinical Development
Job type: Permanent
Salary: £Salary: $Strong salary, bonus, equity and supporting package.
Contact name: Surbhi Dhar

Contact email:
Contact phone: 16179821238
Job ref: 21245
Published: 16 days ago
Expiry date: 29 April 2021

Type: Full Time Permanent

Company Overview

A unique, well-funded, privately held Start-Up with a novel Antibody Therapy platform is seeking a highly motivated individual to lead their Protein Sciences efforts. The company was established in 2019 and has made significant progress in programs with wide therapeutic application in Inflammation, Cardiac diseases and Cancer. It boasts of an intellectually stimulating, positive and collaborative environment with stellar academic and industry leaders as cofounders. This position is highly visible and reports to the CSO.

Job Summary

  • The Principal Scientist, Protein Sciences will be a highly motivated self-starter who has a deep understanding of Protein Biochemistry. The candidate will work on multiple antibody campaigns in close collaboration with the Analytical Sciences team, to lead protein expression and purification efforts of the company.


  • PhD in Biochemistry, Biophysics, Molecular Biology or a related discipline

  • 5+ years of industry experience leading protein biochemistry efforts

  • Solid understanding and experience in protein expression, purification, and downstream characterization

  • Technical expertise in several chromatographic techniques, including but not limited to affinity, size-exclusion, and ion-exchange chromatography on AKTA and FPLC systems

  • Experience with transient and stable protein expression and production in bacterial and mammalian systems is highly preferred

  • Experience with high-throughput protein purification systems will be valuable

  • Exceptional communication skills, both written and oral, and an ability to communicate complex issues to a range of audience

  • Ability to champion innovation across the board to drive organizational improvement in a visible role


  • Build and implement construct design and strategies for optimum protein expression and purification

  • Perform bacterial and mammalian protein expression and purification to contribute to protein production and development

  • Assess protein quality using several biochemical techniques

  • Develop, characterize and execute novel protein-based assays to assess protein purity for selection of a clinical candidate, in collaboration with the Analytical Sciences team

  • Develop high-throughput protein purification strategies using automated liquid handlers

  • Analyze and present data and troubleshoot issues as they arise

  • Foster, nurture and leverage constructive relationships across other internal functional groups

  • Actively collaborate with internal and external partners to achieve key objectives

I manage a range of other permanent and contract positions for a broad portfolio of clients (Biotech, CRO and Pharma). If the above role isn’t for you but you’d nevertheless like to discuss your options in the market, I’d welcome a confidential discussion by phone or email. Contact Surbhi Dhar at +1 (617) 982 1238 or

Salary: $Strong salary, bonus, equity and supporting package.