Senior/Principal Scientist, Analytical Sciences - Antibody Therapy Biotech

Location Boston
Discipline: Pre-Clinical Development
Job type: Permanent
Salary: £Salary: $Strong salary, bonus, equity and supporting package.
Contact name: Surbhi Dhar

Contact email:
Contact phone: 16179821238
Job ref: 21246
Published: 16 days ago
Expiry date: 29 April 2021

Type: Full Time Permanent

Company Overview

A unique, well-funded, privately held Start-Up with a novel Antibody Therapy platform is seeking a highly motivated individual to lead their Analytical Sciences efforts. The company was established in 2019 and has made significant progress in programs with wide therapeutic application in Inflammation, Cardiac diseases and Cancer. It boasts of an intellectually stimulating, positive and collaborative environment with stellar academic and industry leaders as cofounders.

Job Summary

  • The Senior/Principal Scientist, Analytical Sciences will be a highly motivated self-starter with relevant experience in Analytical Development of Protein Biologics. The candidate will have a strong understanding of protein-based assays and work on multiple antibody campaigns in close collaboration with the Protein Sciences team. This will be a visible role reporting to the CSO.


  • PhD in Biochemistry, Biophysics, Molecular Biology, Analytical Chemistry or a related discipline

  • 5 years of industry experience leading protein analytical sciences efforts

  • Solid understanding and experience of protein-based assays like analytical chromatography on HPLC/UPLC, AC-SINS, stability testing, isoelectric focusing, SPR, ITC, DSF, Mass Spectrometry and protein interaction and PTM detection

  • Hands-on experience with characterizing protein biologics like antibodies, enzymes and fusion proteins in an industry setting

  • Experience with transient and stable protein expression and production in bacterial and mammalian systems is highly preferred

  • Experience with high-throughput protein purification systems will be valuable

  • Exceptional communication skills, both written and oral, and an ability to communicate complex issues to a range of audience

  • Ability to learn new skills and adapt to challenges in a fast-paced environment


  • Analyze and qualify different protein modalities using biochemical assays like AC-SINS, HPLC, SDS-PAGE, CE-SDS, endotoxin assay, among others

  • Quantify proteins and study binding using BLI (Octet), SPR, ELISA based Immunoassays and Western Blotting

  • Perform bacterial and mammalian protein purification to make mg quantities of proteins for downstream applications (like PK studies)

  • Work closely with the Protein Sciences team to help with clinical candidate selection

  • Develop high-throughput protein purification strategies using automated liquid handlers

  • Collaborate with external partners to establish novel technologies for the company

  • Analyze and present data, and troubleshoot issues as they arise

  • Foster, nurture and leverage constructive relationships across other internal functional groups

I manage a range of other permanent and contract positions for a broad portfolio of clients (Biotech, CRO and Pharma). If the above role isn’t for you but you’d nevertheless like to discuss your options in the market, I’d welcome a confidential discussion by phone or email. Contact Surbhi Dhar at +1 (617) 982 1238 or

Salary: $Strong salary, bonus, equity and supporting package.