Associate/Director of Computational Chemistry

​

• As the

  ASSOCIATE/DIRECTOR, COMPUTATIONAL CHEMISTRY, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Structural biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects.

• You will contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNA/oligonucleotides, and biologics.

• You will implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts.

​

Responsibilities:

• Responsible for visibility and representation of Computational Chemistry Accomplishments to the executive team.

• Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.

• Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.

• Provide important technical knowledge and input to project teams to drive decision making in drug discovery projects.

• Manage and mentor a Strong team of Computational Chemists to high productivity levels

​

Requirements:

• PhD degree in a Computational Chemistry with 10+ years experience in Pharma/Biotech

• 10+ years of Industry experience including 2+ years in leadership roles and mentoring direct reports is required

• Strong expertise in a variety of computational tools and methodologies including Docking, Virtual screening, Molecular dynamics, Free energy perturbation, Homology modeling, Quantum mechanics, Pharmacophore elucidation, Data mining, Cheminformatics, Clustering, Similarity & Diversity analysis.

• Strong Impact on progressing Discovery Projects from Hits to Clinical Leads

• Strong knowledge & experience in using a variety of tools for Hit ID

• Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints.

• Contribute to the design, development and deployment of AI platforms to impact drug discovery.

• Identify and implement novel computational chemistry algorithms, technologies, and workflows.

• Strong Proficiency with state of the art Computational chemistry software.

• Proficiency in scientific scripting and programming languages