A unique, well-funded, privately held pre-clinical stage biotechnology company with a novel Antibody Therapy platform is seeking a highly motivated individual to lead their Cell Biology efforts. The company was established in 2019 and has made significant progress in programs with wide therapeutic application in Inflammation, Cardiovascular diseases, and Cancer. It boasts of an intellectually stimulating, positive and collaborative environment with stellar academic and industry leaders as cofounders.
Job Summary and Responsibilities
The Cell Biology Expert will be a highly motivated self-starter with a strong background in cell biology, pharmacology and signaling.
The candidate will be part of a team contributing to multiple biologics drug discovery projects in close collaboration with the Antibody Engineering, Membrane Protein Biochemistry and Protein Sciences teams.
She/He will be excited to help explore, identify and validate new targets/mechanisms and support the evaluation of novel biologic candidates.
The position is an opportunity for successful candidates to have a significant impact on the progress of the company’s early pipeline, and contribute to the overall R&D strategy.
This individual needs to be a technical expert, with the drive to contribute to discovery efforts that span a wide range of targets and therapeutic areas.
Expertise in many aspects of cellular biology, assay development, molecular, functional and imaging endpoints is highly desirable
Analytic, creative biologist/immunologist with a background in molecular biology to assist us with developing novel biotherapeutics
Proficient with the culture of primary human cells, in vitro assays and assay development
Expertise in current technology practices in mouse and human immunology desired
Working knowledge and direct experience of a breadth of immunological assays desired
- Capability in designing flow panels and analyzing flow data for mouse/human T/Myeloid cells
- Isolation and culture of primary immune cells human/mouse T/PBMC cell isolation
- CFSE-based T cell proliferation/ Intra-cellular cytokine detection
- Luminex assays, ELISAs
Molecular biology, electroporation and viral transduction, qRT-PCR, Western blot
Addressing questions of cellular MoA and biological targeting in vitro and ex vivo
Leverages strong understanding and knowledge of gene expression and cellular mechanism of action (MOA) for candidate selection and cell-based assay development
Understands and able to design troubleshoot and analyze data for receptor pharmacology experiments,
Practical understanding of a wide range of cell biology techniques such as reporter assays, BRET, FRET and HTRF, and other luminescence and fluorescence-based assays (e.g. calcium-sensitive dyes)
Expertise across a number of therapeutic areas a plus, experience in inflammation/immunology and fibrosis desired
I manage a range of other permanent and contract positions for a broad portfolio of clients (Biotech, CRO and Pharma). If the above role isn’t for you but you’d nevertheless like to discuss your options in the market, I’d welcome a confidential discussion by phone or email. Contact Surbhi Dhar at +1 (617) 982 1238 or firstname.lastname@example.org.
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