Senior Research Scientist - Viral Vectors
Location | Oxford |
Job type: | Permanent |
Contact name: | Thomas Urwin |
Contact email: | thomas.urwin@rbwconsulting.com |
Contact phone: | +44 1293 584 300 |
Job ref: | 27554 |
Published: | 22 days ago |
Expiry date: | 14 Jun 2023 11:59 |
Senior Research Scientist - Viral Vectors
Harwell, Oxford
Competitive Salary
RBW Consulting are delighted to be partnered with a clinical stage T cell immunotherapy company developing products to treat and prevent cancer and infectious diseases. They currently have a Phase 2 clinical trial for prostate cancer and a Phase 1 clinical program for chronic HBV.
An opportunity has arised to lead a small team of vector scientists to develop new vectors for use as vaccines and immunotherapeutics. The successful candidate will play a critical role in the development of new approaches to generate viral vectors alongside performing genetic engineering and characterization of viruses.
Responsibilities:
- Construct and characterise various customised shuttle plasmids for the generation of recombinant viral vectors.
- Clone viral genomes into plasmid or BAC vectors using a variety of techniques.
- Recover engineered candidate viral vectors from cell cultures transfected with viral genomes.
- Characterise rescued viruses, e.g. by genomic sequencing, growth/yield characteristics, etc.
- Participate in developing new methods and processes for the generation of viral vectors.
- Take the lead on early preclinical assessment of suitable candidates, including design of in vitro and in vivo studies.
- Prepare study reports for leadership and manuscripts for publication in scientific journals.
Requirements:
- PhD with at least 4 years of relevant post-PhD experience in molecular virology or viral vectors.
- Solid background in one of the following areas: Virology with extensive molecular cloning/genetic engineering experience OR Viral vector research (vaccines, immunotherapeutics, or gene therapy fields).
- Extensive interpersonal and management skills, with ability to work independently and collaboratively with other scientists and lab staff.
- Meticulous bench working habit, precise record-keeping, and strong organisational and communication skills
- Aptitude for learning new laboratory techniques.
- Attention to detail and ability to accurately record experimental conduct.
- Proficiency in the interpretation and communication of scientific data.
- Excellent written and verbal communication skills; ability to understand and communicate scientific information in English.
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